Description

Berberine HCl 350mg + Ceylon Cinnamon 80mg – Plant-Based Support for Normal Carbohydrate Metabolism

Berberine is one of the most intensively studied plant alkaloids in modern metabolic nutrition science. Extracted from Berberis aristata (Indian barberry) and related Berberis species, Berberine has been used in Traditional Chinese Medicine and Ayurvedic practice for over 2,000 years — originally for digestive and antimicrobial purposes, and more recently studied extensively in the context of carbohydrate and lipid metabolism.

Dr Gabriel’s® Berberine HCl 350mg + Ceylon Cinnamon combines 350mg of pharmaceutical-grade Berberine hydrochloride with 80mg of authentic Ceylon Cinnamon in each vegan capsule — a synergistic formula designed to support normal carbohydrate metabolism, normal blood lipid balance, and general metabolic wellbeing as part of an active, health-conscious lifestyle.

 

What Is Berberine — The Plant Alkaloid Behind the Research

Berberine (chemical name: 5,6-dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium) is a quaternary ammonium alkaloid found in the bark, roots and rhizomes of several plants including Berberis aristata, Berberis vulgaris (barberry), Hydrastis canadensis (goldenseal) and Coptis chinensis (goldthread). Its characteristic bright yellow colour has been used as a dye for centuries.

In modern nutritional science, Berberine is one of the most frequently studied botanical compounds in the area of metabolic function. Its primary documented mechanism of action involves the activation of AMP-activated protein kinase (AMPK) — a cellular energy sensor that plays a central role in regulating glucose uptake, fatty acid oxidation and mitochondrial biogenesis. This AMPK pathway is the same target engaged by the pharmaceutical drug metformin.

Ingredient 1 — Berberine HCl 350mg (Berberis aristata)

Berberine hydrochloride (HCl) is the salt form of Berberine — the most bioavailable and stable form for oral supplementation. At 350mg per capsule and 2–3 capsules daily (700–1050mg Berberine/day), this product delivers a dose in the range most commonly examined in the published scientific literature on Berberine and metabolic function.

 

Ingredient 2 — Ceylon Cinnamon 80mg (Cinnamomum verum)

Ceylon Cinnamon — Cinnamomum verum, also known as ‘true cinnamon’ — is botanically distinct from the more widely available Cassia cinnamon (Cinnamomum cassia or aromaticum). The distinction matters for several reasons: Ceylon Cinnamon contains significantly lower levels of coumarin — a naturally occurring compound found in high concentrations in Cassia cinnamon that carries safety concerns at high doses under EU food safety guidance (EFSA, 2008). At the dose in this formula (80mg/capsule), coumarin content from Ceylon Cinnamon is negligible and within all EU safety parameters.

Ceylon Cinnamon is rich in polyphenolic antioxidants (predominantly proanthocyanidins and cinnamaldehyde) and is traditionally associated with support for normal carbohydrate metabolism and digestive comfort. It complements Berberine’s AMPK-mediated mechanism by enhancing insulin receptor sensitivity through separate pathways — making the combination mechanistically coherent for metabolic support.

 

ℹ️  Ceylon vs. Cassia — Why It Matters: EU EFSA guidance (2008) identified coumarin in cinnamon as a concern at high doses. Cassia cinnamon contains 1–12g coumarin/kg; Ceylon cinnamon contains approximately 0.017g/kg — more than 200 times lower. At the 80mg Ceylon Cinnamon dose in this formula, coumarin intake is far below any safety threshold. This is a meaningful product quality distinction that should be communicated to consumers in AT/DE, where coumarin concerns are well-known.

Active Ingredient Profile — Per Capsule

Component	Content per Capsule	Notes
Berberine HCl (Berberis aristata)	350 mg	Pharmaceutical-grade hydrochloride salt — highest bioavailability form
Ceylon Cinnamon (Cinnamomum verum)	80 mg	True cinnamon — ultra-low coumarin vs. Cassia cinnamon
Capsule shell	HPMC (vegan)	No gelatin — no animal derivatives
Other ingredients	Rice flour (minimal)	Capsule-filling aid only
GMO / Gluten / Soy	None	BEZ GMO | BEZ GLUTENA | BEZ SOJE

 

Nutritional Declaration (per capsule, EU Reg. 1169/2011)

Nutrient	Per 1 Capsule	% NRV
Energy	≈ 1.1 kcal	< 1%
Protein	< 0.1 g	< 1%
Carbohydrates	< 0.1 g	< 1%
Fat	0.0 g	< 1%
Berberine HCl	350 mg	* NRV not established
Ceylon Cinnamon (Cinnamomum verum)	80 mg	* NRV not established

Supported Body Functions

• Supports normal carbohydrate metabolism — Berberine’s AMPK-activating mechanism plays a role in cellular glucose handling, consistent with its 2,000-year traditional use in Chinese and Ayurvedic medicine for metabolic support
• Supports normal blood lipid balance — Berberine has been traditionally used and extensively researched for its role in supporting normal cholesterol and triglyceride levels as part of a balanced diet and healthy lifestyle
• Provides antioxidant support — Ceylon Cinnamon is rich in polyphenolic antioxidants (cinnamaldehyde, proanthocyanidins) that contribute to cellular protection from oxidative stress
• Supports normal digestive comfort — both Berberine and Ceylon Cinnamon have traditional use records for gastrointestinal wellbeing including normal gut motility and digestive balance
• Traditional use: Berberine (Berberis species) has a documented 2,000+ year history of use in Traditional Chinese Medicine (TCM) and Ayurveda for metabolic and digestive support — a well-established phytotherapy record

⚠️  What this product does NOT claim: Berberine does not claim to treat, cure or prevent type 2 diabetes or any other medical condition. It does not claim to lower blood glucose levels as a therapeutic intervention. It does not claim to be an alternative to metformin or any other medication. It does not diagnose or treat insulin resistance as a medical condition. Individuals with diagnosed metabolic conditions must consult their physician.

Who Is This Product For?

• Health-conscious adults aged 35–65 seeking plant-based support for normal carbohydrate metabolism as part of a structured dietary and lifestyle approach
• Research-informed buyers (Emir persona) who have independently investigated Berberine and are looking for a high-dose, pharmaceutical-grade HCl form at a competitive AT/DE market price
• Adults following low-glycaemic, ketogenic, or intermittent fasting protocols who want botanical metabolic support
• Individuals building a metabolic wellness stack alongside complementary products such as Green Tea EGCG or Ashwagandha
• Adults who want the AMPK pathway support of Berberine combined with the complementary mechanism of authentic Ceylon Cinnamon in a single formula

Dosage & Usage Guidelines

Group	Daily Dose	Timing	Notes
Adults (18+) — standard	2 capsules/day	With meals (1 morning + 1 evening)	700mg Berberine/day | 60 caps = 30 days
Adults — higher support	3 capsules/day	With meals (before main meals)	1050mg Berberine/day | 60 caps = 20 days
Children under 18	Not recommended	—	Adults only — not for minors
Pregnant / breastfeeding	Do NOT use	—	Berberine contraindicated in pregnancy
Blood glucose medication	Do NOT use without doctor	—	CRITICAL: metformin, insulin, sulphonylureas — serious hypoglycaemia risk
Blood-thinning medication	Consult physician	—	Berberine may affect anticoagulant metabolism
Autoimmune conditions	Do NOT use	—	Immunomodulating properties

 

Always take with food — Berberine absorption is significantly improved with a meal and gastric discomfort (a common side effect at higher doses on an empty stomach) is reduced when taken with food. Start with 2 capsules/day for the first 2 weeks before increasing to 3 capsules if desired.

Allow 4–8 weeks of consistent daily use to assess full metabolic support effect. Store at room temperature, away from moisture and direct sunlight.

Why Dr Gabriel’s® Berberine + Cinnamon

• 350mg Berberine HCl per capsule — the hydrochloride salt form with highest bioavailability; not raw Berberis powder
• Authentic Ceylon Cinnamon (Cinnamomum verum) — ultra-low coumarin vs. Cassia cinnamon; a meaningful safety and quality distinction
• Dual-mechanism formula — Berberine (AMPK activation) + Ceylon Cinnamon (insulin receptor sensitisation) — synergistic metabolic support
• 60 capsules — 20 to 30-day supply at 2–3 caps/day; full metabolic assessment period in a single pack
• Clean formula — rice flour only as capsule aid; no artificial binders, colours, or preservatives
• Vegan HPMC capsule — no gelatin, no animal derivatives
• GMO-free, gluten-free, soy-free
• Manufactured by KHC-M d.o.o., Mostar — GMP-compliant production
• 60-day unconditional money-back guarantee

 

📋 Disclaimer: This product is a food supplement and not a substitute for a varied diet and a healthy lifestyle. Do not exceed the recommended daily dose. For adults over 18 years only. Not suitable for pregnant or breastfeeding women. Do not use if taking blood glucose-lowering medication (metformin, insulin, sulphonylureas) without prior medical consultation — risk of hypoglycaemia. Do not use if taking blood-thinning medication or immunosuppressive therapies. Not suitable for individuals with autoimmune conditions. Consult a healthcare professional before use if taking any prescription medication. Keep out of reach of children.

FAQ

What is Berberine and how does it work?

Berberine is a plant alkaloid extracted from Berberis aristata and related plants, used in Traditional Chinese Medicine for over 2,000 years. Its primary mechanism of action is the activation of AMPK (AMP-activated protein kinase) — a cellular energy sensor that regulates glucose uptake, fatty acid oxidation, and mitochondrial energy production. AMPK activation is also the mechanism of the pharmaceutical drug metformin, making Berberine one of the most pharmacologically interesting botanical compounds in metabolic nutrition research.

 

What is the difference between Berberine HCl and standard Berberine?

Berberine HCl (hydrochloride) is the salt form of Berberine — the most bioavailable and stable form for oral supplementation. Raw Berberis root powder contains Berberine in a less concentrated and less consistent form, with variable alkaloid content. Berberine HCl guarantees a precise, stable dose of pure Berberine per capsule, is more soluble in the digestive tract, and has superior bioavailability compared to raw plant powder.

 

Why is Ceylon Cinnamon included — and why not Cassia cinnamon?

Ceylon Cinnamon (Cinnamomum verum) is the authentic ‘true cinnamon’ — botanically distinct from the more widely sold Cassia cinnamon. The critical difference: Cassia cinnamon contains high levels of coumarin, which EFSA identified as a safety concern at high doses in 2008. Ceylon Cinnamon contains approximately 200 times less coumarin, making it the safe choice for daily supplementation. It also provides complementary metabolic support through a different mechanism than Berberine, making the combination synergistic.

 

Can I take Berberine if I am on metformin or other diabetes medication?

No — not without explicit guidance from your prescribing physician. Berberine activates the same biochemical pathway (AMPK) as metformin and may significantly potentiate (amplify) the blood glucose-lowering effect of diabetes medications including metformin, insulin, and sulphonylureas. Taking both without medical supervision increases the risk of hypoglycaemia (abnormally low blood sugar). If you take any blood glucose-lowering medication, discuss Berberine supplementation with your physician before use.

 

How long does it take for Berberine to show effects?

Most users report noticeable effects on energy levels, digestive comfort and metabolic wellbeing within 4–6 weeks of consistent daily use at 700–1050mg Berberine per day. Published research on Berberine typically assesses outcomes over 8–12 week periods. For optimal results, take consistently with meals — absorption is significantly improved with food, and gastric tolerance is better when Berberine is not taken on an empty stomach.